European trial of free light chain removal by extended haemodialysis in cast nephropathy (EuLITE): A randomised control trial
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چکیده
منابع مشابه
European trial of free light chain removal by extended haemodialysis in cast nephropathy (EuLITE): A randomised control trial
BACKGROUND Renal failure is a frequent complication of multiple myeloma and when severe is associated with a greatly increased morbidity and mortality. The principal cause of severe renal failure is cast nephropathy, a direct consequence of high concentrations of monoclonal free light chains (FLCs) in patients' sera. FLC removal by extended haemodialysis, using a high cut-off dialyser, has rece...
متن کاملResolution of cast nephropathy following free light chain removal by haemodialysis in a patient with multiple myeloma: a case report
INTRODUCTION Acute renal failure in multiple myeloma is most frequently caused by cast nephropathy, when excess monoclonal free light chains co-precipitate with Tamm-Horsfall protein in the distal nephron, causing tubular obstruction. The natural history of cast nephropathy after diagnosis is unknown. This report provides supporting histological evidence that, as serum free light chain concentr...
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Introduction: Various efforts have been made to reduce post tonsillectomy pain in children. The present study was undertaken to evaluate the efficacy and safety of Ropivacaine in post-operative pain management in these children. Materials and Methods: This study is a Randomized control study on 140 patients between 4 - 12 years of age, in whom tonsillectomy was performed in a ...
متن کاملLymphoplasmacytic lymphoma causing light chain cast nephropathy.
Plasma cell dyscrasias are frequently associated with kidney disease through the production of monoclonal immunoglobulin but with a diverse set of pathologic renal patterns. While almost all patients with a renal biopsy showing a cast nephropathy have myeloma, kidney involvement associated with pathological immunoglobulin light chains and lymphoma is rare. To our knowledge, this is the first re...
متن کاملCombination of bortezomib-based chemotherapy and extracorporeal free light chain removal for treating cast nephropathy in multiple myeloma
Besides amyloidosis and light chain deposition disease, the most common histological type of renal lesion is cast nephropathy in 30% of patients with multiple myeloma [2]. In contrast to amyloidosis, cast nephropathy is believed to be potentially reversible when circulating light chains are rapidly reduced. We report on three patients with multiple myeloma and cast nephropathy treated with a bo...
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ژورنال
عنوان ژورنال: Trials
سال: 2008
ISSN: 1745-6215
DOI: 10.1186/1745-6215-9-55